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KMID : 1022820200110010014
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Journal of Multiple Sclerosis and Neuroimmunology
2020 Volume.11 No. 1 p.14 ~ p.20
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Update of Autoantibodies in Dermatomyositis
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Choi Kyo-Min
Oh Jee-Young
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Abstract
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Dermatomyositis (DM) is a heterogenous autoimmune muscle disease with systemic manifestations including skin lesions and lung involvement. Diagnosis and management have primarily depended on the classification system established by clinical features and muscle biopsy. Current advances of the identification of myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) contribute to exact diagnosis and effective management. In DM, these autoantibodies showed close correlation with clinical characteristics of each subtype. We review the MSAs of DM including anti-melanoma differentiation associated protein 5, anti-Mi-2, anti-transcription intermediary factor 1γ, anti-nuclear matrix protein, and anti-small ubiquitin-like modifier activating enzyme antibodies for comprehensive management of patients.
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KEYWORD
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Dermatomyositis, Autoantibodies, Myositis, Polymyositis
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